William M. JAPANESE RIVALRY OVER THE ANNEXATION OF HAWAII, 1885 1898 (Annapolis: Naval Institute Press, 2011). Sixteen copies are scattered around various branches of the Hawaii Public Library. The paper reported the results of the first 32 patients in a dose finding trial of JCAR014 following a round of chemotherapy, called lymphodepletion, designed to create a more favorable environment for the CAR T cells to grow in the patient’s body. Key findings of the study demonstrated the importance of the choice of lymphodepletion regimen and the effects of different doses of CAR T cells. 50 percent of the 18 patients who were evaluable for efficacy after receiving CAR T cells and chemotherapy agents fludarabine and cyclophosphamide (Cy/Flu) had a complete response, which compares favorably to the 8 percent complete response rate in patients who received JCAR014 plus cyclophosphamide based chemotherapy without fludarabine.
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